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sara

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There seem to be so many contradictions about Mequinol in forums, most of tem not based on science, just claims. In some cases, people lie just to make a point or don’t want to admit that they are wrong.

I don’t claim to know everything about MQ but what I know it is another alternative to monobenzone as depigmenting agent, although a weak one.

· ''Mequinol (hydroquinone monomethyl ether, 4-hydroxyanisole, para-hydroxymethoxybenzene), another derivative of hydroquinone, is enzymatically oxidized by tyrosinase to produce melanocytotoxic quinones. The formation of quinones results in pigment cell destruction and skin depigmentation.''

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· The way Mequinol works is like monobenzone, if you read any definition for Mequinol in dermatology books or journal you will realise that Mequinol works in similar fashion to monobenzone, it will not stay local to the applied area, it works like mono at slower rate, in the link below page 402 it talks about the confetti like hypopigmentation similar to the one produced by mono.

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· The action of Mequinol is not fully understood. It has been approved for the treatment of solar lentigines at 2-4% strength Even on those 2% use, Hypopigmentation was observed on 1% of the patients, although it is concluded to be a safe option at that range.

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· If it was safe at high strength, and can be localised they will be studies to test this. The reason I post this, because so many people who want to try Mequinol do so believing it is only effect the area applied to, and safer than monobenzone.Only low range of Mequinol with retin a used (Solage), because there was a high risk of systemic exposure ‘’ The safety of mequinol in this combination formulation is supported by the low systemic exposures of the subjects in this study compared with the systemic exposures at the highest doses in the dermal toxicity studies in mice (16.6-fold) and rats (34.6-fold)’’ [You must be registered and logged in to see this link.]



· When people hear monobenzone, they think of patches which deter them of using it but not similar information is available on MQ, because simply it has not been tested that much apart from solage. There are no long term studies for its lightening purposes.

· Even its depigmenting ability not greatly tested, the only study was done on "vitiligo universalis" (i.e., patients with more than 70% depigmentation of the total body surface)and only used in small parts as ruby laser also was used on other parts of the skin. In that study the pigment was returned for some patients, ‘’However, even after total depigmentation has been achieved, patients should be warned that perifollicularr repigmentation may occur, especially on sun-exposed areas. A randomized controlled trial is needed to confirm these findings’’.

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MAHARANI

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Thanks sara for posting that info. I have come across some of it before but like you said there does not seem to still be enough info on how this really works. It may well give patches and as you mentioned before someone said he is experiencing this now. It is diffcult as well, because some are using concentrations higher than suggested and this again may give results other than is expected. I have used it , not on daily basis, and in a weaker version than the 10% I received, but even I do not know what to expect. I guess the best we can do is to keep researching and making sure that close observations are made during the process.

.


.

sara

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Maharani, as long as you diluting it, you will be ok hopefully, I think solage is been found to be effective, mainly for two things, the amazing retin a, and its high alcohol content, which mean greater absorption.

Golden Girl

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Thanks for the info and studies. I recall researching a few months back that at higher percentages of mequinol such as 20% can depiment the skin, and lighten at lower concentrations such as 2%. Unfortunately, I have been unable to find a generic version percentage less than 10%. The Solage name brand which is considerably more expensive and needing a prescription. I think that if it's used at a lower strength (lower than 15-20%) and used along with tretinoin, the chance of white spots are lessened. So far, those who I'm aware of using mequinol 10% or less hasn't experienced spotting, as of yet anyways. I think anyone using higher than 10% risks a higher chance? 20%, maybe even 15%, causing depigmentation but at a slower rate in some in comparison than monobenzone?


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
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http://theskinphilosophy.forumotion.net

sara

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Golden Girl wrote:Thanks for the info and studies. I recall researching a few months back that at higher percentages of mequinol such as 20% can depiment the skin, and lighten at lower concentrations such as 2%. Unfortunately, I have been unable to find a generic version percentage less than 10%. The Solage name brand which is considerably more expensive and needing a prescription. I think that if it's used at a lower strength (lower than 15-20%) and used along with tretinoin, the chance of white spots are lessened. So far, those who I'm aware of using mequinol 10% or less hasn't experienced spotting, as of yet anyways. I think anyone using higher than 10% risks a higher chance? 20%, maybe even 15%, causing depigmentation but at a slower rate in some in comparison than monobenzone?

Yes in lower doses MQ especially with retin a sounds promising, but as you said at higher percentage, there re high risk they will be patches.

As depigmenting agent, I am not big fan of MQ, in the above studies 20% was used to depigment but some experienced repigmentation to the treated area after few months.

That risk exist even for mono but more for MQ.

LiteNYellow

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How is mequinol mixed if you get it in powder form? If it's measured at a low percentage, say 5%. Then add your retin A, then this can be a cheaper alternative and you can control the strength easier. Unless All Day Chemist sell it at different strengths.

MAHARANI

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sara wrote:
Yes in lower doses MQ especially with retin a sounds promising, but as you said at higher percentage, there re high risk they will be patches.

As depigmenting agent, I am not big fan of MQ, in the above studies 20% was used to depigment but some experienced repigmentation to the treated area after few months.

That risk exist even for mono but more for MQ.

sara, I was trying to find that section, but can I ask, is that repigmentation, after the MQ application was stopped or whilst it was still being used?


.

MAHARANI

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LiteNYellow,

I know of one person who says she has been able to obtain the MQ in it's raw form and has been able to easily disolve it, just by mixing it into her base cream. Nothing more technical than that apparently.

Several people have conatcted All Day chemist requesting that they stock MQ, as at the moment it is not one of their products. They have said that there are no plans to do so, but we will have to see. At the moment the only obtainable place is goldpharma who are currently stocking 10 -20 % MQ.

sara

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MAHARANI wrote: I was trying to find that section, but can I ask, is that repigmentation, after the MQ application was stopped or whilst it was still being used?


.

from the study
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’Off the 11 patients who responded to the 4-MP cream, 4 had recurrence of pigmentation

(relapse rate of 36%; 95% CI, 11% to 69%) after a treatment-free period between 2 and

36 months. The pigment returned mostly in a perifollicular pattern. In 1 patient, pigment

returned almost entirely (Figure 2). This patient attributed the relapse to a sunny holiday

inn Morocco. Two other patients also attributed the relapse to unintentional sun exposure.

One reported that return of pigmentation occurred after a ski holiday (no. 15)’’

sara

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MAHARANI wrote:LiteNYellow,

I know of one person who says she has been able to obtain the MQ in it's raw form and has been able to easily disolve it, just by mixing it into her base cream. Nothing more technical than that apparently.

Several people have conatcted All Day chemist requesting that they stock MQ, as at the moment it is not one of their products. They have said that there are no plans to do so, but we will have to see. At the moment the only obtainable place is goldpharma who are currently stocking 10 -20 % MQ.
I agee nothing fancy MQ, is like mono it dissolve in alcohol, with base cream, and some nice smelling stuff to mask the smell lol.

MAHARANI

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sara, thanks for pointing that out. Hopefully with appropriate maintenance and very good sun protection and avoidance, then this should help regressing back to your starting colour.

.

Kandiluv

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Is mequinol more like hq or more like mono? or is it like neither?

Golden Girl

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Mequinol (4-methoxyphenol) is the monomethyl ether of hydroquinone.
Meq can be used as a depigmenting agent in higher concentrations or as a lightening agent in lower concentrations.

Monobenzone (4-(benzyloxy)phenol) is the monobenzyl ether of hydroquinone.


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_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
[You must be registered and logged in to see this link.]
http://theskinphilosophy.forumotion.net

Golden Girl

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Do you consider it ideal to use ethanol alcohol to dissolve mequinol? Or what types of alcohol is best?


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
[You must be registered and logged in to see this link.]
http://theskinphilosophy.forumotion.net

sara

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Golden Girl wrote:Do you consider it ideal to use ethanol alcohol to dissolve mequinol? Or what types of alcohol is best?

Yes Ethanol sounds good solvent, the only problem with it is irritation cause by it but at low does of mequinol it should not be a problem. Solage is prepared with 2% MQ, and 77% ethanol also Retin a. That why it works fast, ethanol is great for absorption, it side effect is that can cause irritation, that why with monobenzone can be very harsh on the skin.

Alizee love

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Ok I may try mq but am unsure.

From what I gather I should use a low 5% right?
Ok but how often should I apply it?
Where can I buy it and how much for a one month supply?
How do I maintan my desired colour?
Can I switch to hq with ret a to maintan my new shade with the mq?
How do I dilute the 10%? I need like a step by step breakdown lol


Oh and for sara: is that you in your avitar?

sara

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Alizee love wrote:Ok I may try mq but am unsure.

From what I gather I should use a low 5% right?
Ok but how often should I apply it?
Where can I buy it and how much for a one month supply?
How do I maintan my desired colour?
Can I switch to hq with ret a to maintan my new shade with the mq?
How do I dilute the 10%? I need like a step by step breakdown lol


Oh and for sara: is that you in your avitar?

Hi,

Well with MQ we still don’t know a lot about it, I posted what information available but there is another thread I posted called mg my theory, explaining why it might not bring patches. If someone want to take the risk as there is little available about it.

Anyhow at smaller percentage it has been studied a lot. If you want to use MQ then use it twice with retin a, and to maintain result, I think you can also use it to do that, and avoiding the sun etc.

Now if you want to make 5% out of the 10% cream you have, you just need to dilute it by half for example if you have 100g of 10%MQ, then you need another 100g base cream to get 5% of MQ.



The avatar lol I wish, it is in my opinion the most pretty actress in the middle east, Syrian actress sulaf fawakherji

MAHARANI

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sara,

Your actress has a touch of Elizabeth Taylor about her. She is very beautiful.
.

Alizee love

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sara wrote:
Alizee love wrote:Ok I may try mq but am unsure.

From what I gather I should use a low 5% right?
Ok but how often should I apply it?
Where can I buy it and how much for a one month supply?
How do I maintan my desired colour?
Can I switch to hq with ret a to maintan my new shade with the mq?
How do I dilute the 10%? I need like a step by step breakdown lol


Oh and for sara: is that you in your avitar?

Hi,

Well with MQ we still don’t know a lot about it, I posted what information available but there is another thread I posted called mg my theory, explaining why it might not bring patches. If someone want to take the risk as there is little available about it.

Anyhow at smaller percentage it has been studied a lot. If you want to use MQ then use it twice with retin a, and to maintain result, I think you can also use it to do that, and avoiding the sun etc.

Now if you want to make 5% out of the 10% cream you have, you just need to dilute it by half for example if you have 100g of 10%MQ, then you need another 100g base cream to get 5% of MQ.



The avatar lol I wish, it is in my opinion the most pretty actress in the middle east, Syrian actress sulaf fawakherji
thanks for the advice, I did read the facts, what little there are.
what do you mean byuse it twice?
so i just apply it once a day untill i reahc my desired shade and then do maintanence right?
Maharani I agree she is very pretty, she reminds me of a bollywood actress

Alizee love

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this is a question for those that have used mq, I asked this in anohter thread and thought I would ask it here as well.

After you nolonger used the MQ did you return to your shade whenyou first statred or did you return to a shade slightly lighter then when you started?

Golden Girl

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I also noticed there is more studies for mq 2%/ra 0.1% for correcting solar lentigines. And much higher percentages such as 20% to help depigment overall skin. But, it seem as though not much studies with testing Mq 4-6%/Ra to lighten overall skin.

Sara, what are the proper measurements are needed to dilute the strength in order to make 5% mq strength/0.1% Ra strength with this if possible?:

Mequinol 10% 20g ("creme", yet is more like petroleum)
Tretinoin 0.4% 20g ("creme")


is it ok to use base as:
E45 cream 500g
or
Eucerin lotion 479.10g (16.9oz)


Or what exactly should be used as the base in large enough quantity for the body?


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
[You must be registered and logged in to see this link.]
http://theskinphilosophy.forumotion.net

sara

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GG if you have 20g of MQ at 10% all you need is to double that with base cream. Now you chose eucrine or E45 I am sure both are ok, as they are both oil based but E45 is more thicker so it might blend well, so to make 5% of your cream, you take the whole 20g of your MQ and mix it with 20g of E45, in total you will have 40g mq with 5% strength

Alizee love

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Did you get yours at goldpharna gg?
As you can tell I'm still unsure of wha to start with.
Sigh....so many choices:
Hq with ret a
Mq 20% (unsure on how to dilute)
Makari
Pure perfect( I really wanna get light like that actress did but don't know what she used)

You can all see my dilema lol

Emo chik

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Mequinol I never heard of. Is it a really good lightener? I don't want to use monobenzone from reading about it so far. But mequinol how much lighter can it make you?

Alizee love

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Sara wrote her own theory on it if you want to read it.
I am new to all this but the impression I have gotten is that these products might not work well for everyone since we all have different skin. I have read of people getting four shades lighter but I believe that was after prolonged use and at a high percentage.

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