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Golden Girl

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Mequinol 2%/Tretinoin 0.01% solution: an effective and safe alternative to Hydroquinone 3% in the treatment of solar lentigines.

Here is a study that I had recently read and found interesting, which gives the comparison of Mequinol 2% used along with Tretinoin 0.01% (Retin-A) and Hydroquinone 3% (Tretinoin was not mentioned to be used along with Hq in this study). 216 individuals were advised to use this regimen twice daily on lentigines &/or lesions (liver spots and scarring) for 4 months (16 weeks).

To my understanding, Mq 2% is normally prescribed along with 0.1% tretinoin (which is the known highest strength that is commonly prescribed to help the skin exfoliate) and not 0.01% (which is far less, as 0.025% is normally prescribed and commonly known as the lowest dosage. In conclusion of this study, they have stated that Mq 2%/Tret. 0.01% had far succeeded as a better skin lightening agent than the Hq 3%. Keep in mind though that an exfoliant such as Tretinoin was not mentioned to be used along with Hq in this study. The individuals' skin also did not have severe adverse reactions. Only mild to moderate reactions which to my knowledge, may have been only mild irritation, dryness, and itching of the skin which is quite common with Mq and Hq.


Here is the study below:

A new topical solution containing 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% (Solagé) was compared with its active components, its vehicle, and hydroquinone (HQ) 3% in the treatment of solar lentigines. In a randomized, parallel-group, double-masked study, 216 subjects applied the treatments twice daily for 16 weeks and were followed up for a further 24 weeks. A significantly higher proportion (P < or = .05) of subjects achieved clinical success with mequinol 2%/tretinoin 0.01% compared with HQ 3% as measured by both the lesional pigmentation on the forearm and the physician global assessment at the end of treatment. The proportion of subjects achieving clinical success on the face in the mequinol 2%/tretinoin 0.01% group was consistently higher than that in the HQ 3% group. Some treatment effects remained at the end of the treatment-free follow-up, with trends apparent on the face in favor of mequinol 2%/tretinoin 0.01% over HQ 3%. In all treatment groups, skin-related adverse events were mild or moderate and transient. In conclusion, the mequinol 2%/tretinoin 0.01% solution is a highly effective and well-tolerated treatment for solar lentigines and related hyperpigmented lesions, being superior to HQ 3% for lesions on the forearm and of similar efficacy for lesions on the face.

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My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
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allure

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Thank you GG. I saw that study online when I decided to purchase the MQ. There are some good and some bad but with everything again caution needs to be exercised. Interesting study and a lot of people have had success with the mix. I am guessing too that HQ3% can be just as effective if used in conjunction with Tret.
I don't think I would be able to use MQ10 at full strength as I am looking to enhance than damage. LOL.

Golden Girl

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Thanks Allure, yes an interesting study. I use nadinola extra strength which contains 3% Hq and it has gradually lightened my neck and ears to a light brown and it doesn't give me that pinkesh look that Hq 4% commonly gives. I can only imagine how much more effective Hq 3% would be on my neck and ear areas if I used retin-a there. But, the peeling and irritation was really bad on my neck for me using it on those locations, so I eventually switched to using just the neutrogena pink grapefruit scrub instead which is more gentle.


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
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MAHARANI

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I have heard of several people having problems using Retin A and peels on the neck area. I guess I did not realise how sensitive this area is. I have used Retin A on my neck with no problems so far, but my neck got really irritated with a very mild lactic acid peel, and yet my face had absolutely no problem with the same solution.



.

MAHARANI

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just to aadd, thanks for that info, GG.It is a shame that we have still not been able to find a supplier able to provide the 2 % without a prescription.

Golden Girl

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Thanks Maharani, I guess it's another product that works better or worse on different parts of the body. Using nadinola has helped my neck to lighten and reach the same shade as my shoulders and upper body, in which my neck used to be darker since it was exposed to sunlight without sunblock. My face is slowly ketching back up and about a shade darker than my neck.


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
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http://theskinphilosophy.forumotion.net

Golden Girl

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I often wonder as well how come 2% mequinol strength is rarely offered, and yet 10% is much easier to obtain?? If 2% mq is commonly the standard it would only make since unless there is another reason as to why.


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
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http://theskinphilosophy.forumotion.net

MAHARANI

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And the huge price difference between the 2% combined products like Solage for example. and the 10% MQ from Goldpharma is ridiculous. Why so much for the extra tretinoin etc added ?

Golden Girl

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I don't know, my guess would be for paying for the name instead of the actual product. As though name alone will lighten skin.


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
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http://theskinphilosophy.forumotion.net

allure

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GG I tend to agree with you. We are just paying for the name of the product and not the actual cost of the product. It is a shame that people have to use other sources to obtain products that are readily available but need either a prescription or cost an arm and a leg.

yes___I mean no

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hey it's my first time here and i'm lov'in it.
so, today at 10:30 a.m my retin-a came in the mail,OH YEAH. just took 4 days to come and it only cost 4 dollars for every 20 g tube,WHAAAAAAT!thats right, just waiting for the mequinol. but those results of the study are reassuring that i'm walking down the yellow brick road of lighting success. no need for an applause, but feel free to clap anyway cheers

cordellpuss


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Yes I mean no Wrote:
hey it's my first time here and i'm lov'in it.
so, today at 10:30 a.m my retin-a came in the mail,OH YEAH. just took 4 days to come and it only cost 4 dollars for every 20 g tube,WHAAAAAAT!thats right, just waiting for the mequinol. but those results of the study are reassuring that i'm walking down the yellow brick road of lighting success. no need for an applause, but feel free to clap anyway cheers


Hey!!! you are so funny i'm going to applaud you anyways, i wish you lots of success with your skin lightening regrimen.

Golden Girl

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yes___I mean no wrote:hey it's my first time here and i'm lov'in it.
so, today at 10:30 a.m my retin-a came in the mail,OH YEAH. just took 4 days to come and it only cost 4 dollars for every 20 g tube,WHAAAAAAT!thats right, just waiting for the mequinol. but those results of the study are reassuring that i'm walking down the yellow brick road of lighting success. no need for an applause, but feel free to clap anyway [You must be registered and logged in to see this image.]

LOL.. clap clap!

I'm glad your retin-a arrived and much success to you. What percentage did you get?

My first couple of months with Ra were the toughest, especially since I have sensitive skin. Fast track several months later, my skin has erally smoothed out, no acne breakouts anymore, and almost blemish free on my face as the hyperpigmented spots has almost completely faded. I think the glycolic acid/mulberry serum helped me progress as well.


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
[You must be registered and logged in to see this link.]
http://theskinphilosophy.forumotion.net

yes___I mean no

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Golden Girl wrote:
yes___I mean no wrote:hey it's my first time here and i'm lov'in it.
so, today at 10:30 a.m my retin-a came in the mail,OH YEAH. just took 4 days to come and it only cost 4 dollars for every 20 g tube,WHAAAAAAT!thats right, just waiting for the mequinol. but those results of the study are reassuring that i'm walking down the yellow brick road of lighting success. no need for an applause, but feel free to clap anyway [You must be registered and logged in to see this image.]

LOL.. clap clap!

I'm glad your retin-a arrived and much success to you. What percentage did you get?

My first couple of months with Ra were the toughest, especially since I have sensitive skin. Fast track several months later, my skin has erally smoothed out, no acne breakouts anymore, and almost blemish free on my face as the hyperpigmented spots has almost completely faded. I think the glycolic acid/mulberry serum helped me progress as well.


i received 0.1%, i heard that was a lot especially for first time us and i dont want to end up with a red face Embarassed but it will be properly diluted.

it came yesterday, well the 25 (don't know what time zone your in)
i have not used it yet, still waiting for the mequinol,

but i'm known for getting creams in my eye pirat have to be more careful lol!

and hey is that guy holding the lol sign Goku, just a thought

Golden Girl

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LMAO Gou from Dragon Ball Z! lol..maybe. I used to be sooo addicted to that anime, it does kind of look like him and maybe he is laughing at us. With my hq I use 0.05% ra, but I have also used 0.1% for acne spots on my face which helped but was so much stronger. So I later just switched back to 0.05%.


_________________
My Current Skin Lightening Regimen Is:
Neutrogena Acne Wash Pink Grapefruit Foaming Scrub (cleanser)
Tretinoin/Retin-A 0.05% (exfoliant)
All Day Chemist Hq 4% (lightener)
RX Suncare: Sport Sunblock SPF 50 (sunblock)
-----------------------------------------------
[You must be registered and logged in to see this link.]
http://theskinphilosophy.forumotion.net

yes___I mean no

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Golden Girl wrote:LMAO Gou from Dragon Ball Z! lol..maybe. I used to be sooo addicted to that anime, it does kind of look like him and maybe he is laughing at us. With my hq I use 0.05% ra, but I have also used 0.1% for acne spots on my face which helped but was so much stronger. So I later just switched back to 0.05%.

0.05... i'll have to try that GG, oh and they play dragon ball z on tv again, just started on Monday in america.

well don't know what time it is over there but it's 2:00 a.m over here,
good night everyone Sleep

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