Tue Jul 19, 2016 4:27 am by vairclair1
Mequinol 2% (w/ tretinoin0.01%) vs. Hydroquinone 3% Wed May 19, 2010 11:52 pm
Golden Girl
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Mequinol 2%/Tretinoin 0.01% solution: an effective and safe alternative to Hydroquinone 3% in the treatment of solar lentigines.
Here is a study that I had recently read and found interesting, which gives the comparison of Mequinol 2% used along with Tretinoin 0.01% (Retin-A) and Hydroquinone 3% (Tretinoin was not mentioned to be used along with Hq in this study). 216 individuals were advised to use this regimen twice daily on lentigines &/or lesions (liver spots and scarring) for 4 months (16 weeks).
To my understanding, Mq 2% is normally prescribed along with 0.1% tretinoin (which is the known highest strength that is commonly prescribed to help the skin exfoliate) and not 0.01% (which is far less, as 0.025% is normally prescribed and commonly known as the lowest dosage. In conclusion of this study, they have stated that Mq 2%/Tret. 0.01% had far succeeded as a better skin lightening agent than the Hq 3%. Keep in mind though that an exfoliant such as Tretinoin was not mentioned to be used along with Hq in this study. The individuals' skin also did not have severe adverse reactions. Only mild to moderate reactions which to my knowledge, may have been only mild irritation, dryness, and itching of the skin which is quite common with Mq and Hq.
Here is the study below:
A new topical solution containing 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% (Solagé) was compared with its active components, its vehicle, and hydroquinone (HQ) 3% in the treatment of solar lentigines. In a randomized, parallel-group, double-masked study, 216 subjects applied the treatments twice daily for 16 weeks and were followed up for a further 24 weeks. A significantly higher proportion (P < or = .05) of subjects achieved clinical success with mequinol 2%/tretinoin 0.01% compared with HQ 3% as measured by both the lesional pigmentation on the forearm and the physician global assessment at the end of treatment. The proportion of subjects achieving clinical success on the face in the mequinol 2%/tretinoin 0.01% group was consistently higher than that in the HQ 3% group. Some treatment effects remained at the end of the treatment-free follow-up, with trends apparent on the face in favor of mequinol 2%/tretinoin 0.01% over HQ 3%. In all treatment groups, skin-related adverse events were mild or moderate and transient. In conclusion, the mequinol 2%/tretinoin 0.01% solution is a highly effective and well-tolerated treatment for solar lentigines and related hyperpigmented lesions, being superior to HQ 3% for lesions on the forearm and of similar efficacy for lesions on the face.
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Here is a study that I had recently read and found interesting, which gives the comparison of Mequinol 2% used along with Tretinoin 0.01% (Retin-A) and Hydroquinone 3% (Tretinoin was not mentioned to be used along with Hq in this study). 216 individuals were advised to use this regimen twice daily on lentigines &/or lesions (liver spots and scarring) for 4 months (16 weeks).
To my understanding, Mq 2% is normally prescribed along with 0.1% tretinoin (which is the known highest strength that is commonly prescribed to help the skin exfoliate) and not 0.01% (which is far less, as 0.025% is normally prescribed and commonly known as the lowest dosage. In conclusion of this study, they have stated that Mq 2%/Tret. 0.01% had far succeeded as a better skin lightening agent than the Hq 3%. Keep in mind though that an exfoliant such as Tretinoin was not mentioned to be used along with Hq in this study. The individuals' skin also did not have severe adverse reactions. Only mild to moderate reactions which to my knowledge, may have been only mild irritation, dryness, and itching of the skin which is quite common with Mq and Hq.
Here is the study below:
A new topical solution containing 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% (Solagé) was compared with its active components, its vehicle, and hydroquinone (HQ) 3% in the treatment of solar lentigines. In a randomized, parallel-group, double-masked study, 216 subjects applied the treatments twice daily for 16 weeks and were followed up for a further 24 weeks. A significantly higher proportion (P < or = .05) of subjects achieved clinical success with mequinol 2%/tretinoin 0.01% compared with HQ 3% as measured by both the lesional pigmentation on the forearm and the physician global assessment at the end of treatment. The proportion of subjects achieving clinical success on the face in the mequinol 2%/tretinoin 0.01% group was consistently higher than that in the HQ 3% group. Some treatment effects remained at the end of the treatment-free follow-up, with trends apparent on the face in favor of mequinol 2%/tretinoin 0.01% over HQ 3%. In all treatment groups, skin-related adverse events were mild or moderate and transient. In conclusion, the mequinol 2%/tretinoin 0.01% solution is a highly effective and well-tolerated treatment for solar lentigines and related hyperpigmented lesions, being superior to HQ 3% for lesions on the forearm and of similar efficacy for lesions on the face.
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but it will be properly diluted. 
have to be more careful 
